Abstract
Epilepsi merupakan gejala penyerta yang sering terjadi pada anak-anak penderita Cerebral Palsy (CP). EEG merupakan salah satu Gold Standard untuk mendeteksi adanya gelombang aktivitas epilepsi yang terjadi pada anak-anak dengan CP. Tujuan dari penelitian ini adalah untuk mengetahui angka kejadian dan prevalensi Epilepsi pada anak penderita CP. Penelitian ini berupa deskriptif analitik, data diperoleh secara retrospektif terhadap penderita yang memenuhi syarat diagnosis CP dengan epilepsi. Diagnosis ditegakkan berdasarkan telaah rekam medis meliputi anamnesis, pemeriksaan fisik dan neurologis serta pemeriksaan penunjang berupa EEG dan MRI Kepala. Prevalensi penderita CP dengan epilepsi pada penelitian ini adalah 108%. Tipe epilepsi terbanyak pada penderita CP adalah general yaitu 160 penderita (83%), sementara tipe fokal hanya 32 penderita (17%). Pada penderita CP dengan epilepsi, tipe CP terbanyak adalah tetraparesis (81%). Pada penderita CP tanpa epilepsi, tipe CP terbanyak adalah tetraparesis (51 penderita; 65.38%). Gambaran EEG terbanyak pada penderita CP dengan epilepsi adalah multifokal (56%), diikuti perlambatan (26%) dan unifokal (18%). Prevalensi penderita cerebral palsy dengan epilepsi pada penelitian ini mencapai 1.08%. Penderita CP dengan epilepsi mengalami epilepsi tipe general lebih banyak dibandingkan fokal. Sebagian besar penderita cerebral palsy dengan epilepsi mengalami tipe tetraparesis. Sebagian besar gambaran EEG pada penderita cerebral palsy dengan epilepsi adalah multifokal.
References
Aydin K, Kartal A. High rates of malnutrition and epilepsy: two common comorbidities in children withcerebral palsy. Turk J Med Sci(2019) 49: 33-37.
Boyle CA, Boulet S, Schieve LA, et al. Trends in the prevalence of developmental disabilities in US children, 1997–2008. Pediatrics 2011; 127:1034–42
Boulet SL, Boyle CA, Schieve LA. Health care use and health and functional impact of developmental disabilities among US children, 1997–2005. Arch Pediatr Adolesc Med 2009;163:19–26.
Bruck I, Antoniuk AS, Spessatto A, Hausberger R, Pacheco CG. Epilepsy in children with cerebral palsy. Arq Neuropsiquatr 2001; 59(1): 35-9.
Centers for Disease Control and Prevention. Data & Statistics for Cerebral Palsy. Accessed August 10, 2013.
Christensen D, Van Naarden Braun K, Doernberg NS, et al. Prevalence of cerebral palsy, co-occurring autism spectrum disorders, and motor functioning. Autism and Developmental Disabilities Monitoring Network, USA, 2008. Dev Med Child Neurol 2014;56:59–65.
Chiang Kuo-Liang, Kuo Fang-Chuan, Cheng Chen-Yang, Chang Kai-Ping. Prevalence and demographic characteristics of comorbid epilepsy in children and adolescents with cerebral palsy: a nationwide population-based study. Childs Nerv Syst. 2018
Elsevier, Shubhra M, Deborah J. Braddom RL. Cerebral palsy. Physical Medicine & Rehabilitation 3rd ed.2007. 1243–61.
El-Tallawy HN, Farghaly WM. Epileptic and cognitive changes in children with cerebral palsy: an Egyptian study. Neuropsychiatric Disease and Treatment 2014:10 971–975.
Fishbacker E. Effect of reduction of anticonvulsants on well being. BMJ 1982; 285: 423-4
Gamayani U. Epilepsi pada anak dengan cerebral palsy. 2003. Universitas Padjajaran Bandung.
Gurkan F, Gokben S. Determining Risk Factors of Epilepsy in Childrenwith Cerebral Palsy: A Retrospective Study.J Pediatr Res 2018;5(2):76-81.
International League Against EpilepsyCommission on Classification and Terminology of the International League Against Epilepsy, Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989;30:389–99.
Jacobs IB. Epilepsy. In: Thompson GH, Rubin IL, Bilenker RM, editors. Comprehensive management of cerebral palsy. New York: Grune and Stratton, 1983. p. 131–7.
Joghataei M, Kazem M. Assessment the Level of Community Needs in Welfare Services on the Whole Country. 1st ed.1990;Tehran: University of Social Welfare and Rehabilitation Sciences.
Kwong Kl, Wong Sn, So Kt. Epilepsy In Children With Cerebral Palsy. Pediatr Neurology 1998;19:31-36.
Kulak W, Wojciech Sobaniec. Risk Factors And Prognosis Of Epilepsy In Children With Cerebral Palsy In North-Eastern Polan. Brain And Development 27 (2003) 499-506.
Kancherla V, Amendah DD, Grosse SD, et al. Medical expenditures attributable to cerebral palsy and intellectual disability among Medicaid-enrolled children. Res Dev Disabil 2012;33:832–40.
Kholin A. Cerebral Palsy and Epilepsy. Intech Open. 2018.
Levene M. The clinical conundrum of neonatal seizures. Arch Dis Child Fetal Neonatal Ed 2002;86:F75–7.
Mutch L, Alberman E, Hagberg B, Kodama K, Perat MV. Cerebral palsy epidemiology: where are we now and where are we going? Dev Med Child Neurol 1992;34:547–55.
Mattson RH. The role of the old and the new antiepileptic drugs in special populations: Mental and multiple handicaps. Epilepsia 1996; 37: S45-53.
National Institute of Neurological Disorders and Stroke, National Institutes of Health. Cerebral Palsy: Hope Through Research, NIH Publication. 2013 July; No.13-159. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Cerebral-Palsy-Hope-Through-Research#3104_21.
Narenji F, Rosbahany N. The effects of Tuina therapy on weight gain and sleep behaviors in infants. Koomesh 2008;9:279. 14–84. 14.]
Perdossi. 2014 Pedoman Tatalaksana Epilepsi. Surabaya: Airlangga University Press.
Paediatric Neurology 2nd Edn Oxford Specialist Handbooks In Paediatrics Edited By Forsyth Rob And Newton Richard Oxford: Oxford University Press, 2012
Pakula AT, Van Naarden Braun K, Yeargin-Allsopp M. “Cerebral plasy: classification and epidemiology.” In: Michaud LJ, editor. Cerebral Palsy, Volume 20, Number 3. Philadelphia, PA: W.B. Saunders Company; 2009:437.
Potharaju NR. Seizures in cerebral palsy. Indian J Cereb Palsy 2016;2:3-21.
Ratnawongsa B. Cerebral Palsy. Dalam: E- Medicine Journal, 2001, Volume 2, Number 2. Diambil Dari Internet Di Http: // Www. E-Medicine.Com
Rosenbaum P, Paneth N, Leviton A, et al. A report: the definition and classification of cerebral palsy April 2006. Dev Med Child Neurol Suppl 2007;109:8–14.
Swaiman Kf, Ashwal. Pediatric Neurology, Principles, And Practice ( 3 Rd Ed), Mosby, St. Louis, 1999: 312-22
Suartaman, Putu. Prevalensi Dan Faktor-Faktor Risiko Palsi Serebral Pada Anak Di Laboratorium Ilmu Kesehatan Anak Rsup Sanglah Denpasar. Fakultas Kedokteran Universitas Udayana, Bali, 1998. Tesis.
Shankaran S. Prevention, diagnosis, and treatment of cerebral palsy in near-term and term infants. Clin Obstet Gynecol 2008;51:829–39.
Svraka E. Children with cerebral palsy and epilepsy. Epilepsy-Histological, Electroencephalographic and Psychological Aspects. 2012. 251-276. InTech Europe.
Suzuki J, Ito M, Tomiwa K, Okuno T. A clinical study of cerebral palsy in Shifa; 1977-1986. Severity of the disability and complications in various types of cerebral palsy. No To Hattatsu. Jul 1999; 31 (4): 336-42.
Sianturi Pertin. Kejadian epilepsi pada penderita serebral palsi di Yayasan Pembinaan Anak Cacat di Medan. Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Sumatera Utara, 2001. Tesis.
Suzuki J, Ito M, Tomiwa K, Okuno T. A clinical study of cerebral palsy in Shifa; 1977-1986. Severity of the disability and complications in various types of cerebral palsy. No To Hattatsu. Jul 1999; 31 (4): 336-42.
Trevathan E, Murphy CC, Yeargin-Allsopp M. Prevalence and descriptive epidemiology of Lennox–Gastaut syndrome among Atlanta children. Epilepsia 1997;38:1283–8.
Vohr BR, Wright LL, Dusick AM. Differences and outcomes of extremely low birth weight infants. Pediatrics 2004;113:781.
Wei SHI, Hong YANG, Bing-pei SHI, et al. Effects of motor-development massage therapy on gross motor function in childrenwith cerebral palsy. Chin J Evid Based Pediatr 2007;2:354–63.
Wibowo, AR dan Saputra, DR. Prevalens dan profil klinis pada anak palsi serebral spastik dengan epilepsi. Sari Pediatri. 2012; 14 (1): 1-7.